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This study was designed to determine whether mechanical stress affects the expression of IL-1β and PDGF in VSMCs, and to further analyze the underlying mechanisms. VSMCs were stimulated with cyclic mechanical stretch or compression. Mechanical stretch or compression increased the expression of IL-1β and PDGF mRNA and protein in a time-dependent manner. These effects were inhibited by the p38 MAPK inhibitor SB203580. Furthermore, the expression of IL-1β mRNA and protein induced by mechanical stretch was time-dependent, and SB203580 inhibited the expression of IL-1β induced by mechanical stretch. Furthermore, overexpression of IL-1β enhanced the expression of PDGF induced by mechanical stretch in VSMCs. The specific protease inhibitor N-p-tosyl-L-phenylalanine chloromethyl ketone decreased IL-1β-induced PDGF expression in VSMCs. These data indicate that mechanical stress facilitates the expression of IL-1β and PDGF via p38 MAPK in VSMCs. 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Point of Impact Television Network Point of Impact Television Network (POTN) (also known as Point of Impact in the US) is a Canadian international non-commercial educational television network. Mission Point of Impact Television Network is a non-profit corporation which produces television documentaries on contemporary issues of the world’s religions and religious themes. It has been described as a "not-for-profit media corporation" that creates programs that are "of interest to a wide audience" and "help people understand religion and religious institutions in a pluralistic world". History The network was founded in 1998 by the Religious Studies Centre of the University of Manitoba. In 2015, POTN was bought by the Roman Catholic Archdiocese of Winnipeg and renamed as Point of Impact. Programmes Besides documentaries, POTN also produces live debates, talks and discussions as well as 30-minute radio programmes. 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The straightforward way (as far as I could tell, and as I would do in Java) would be to create a Custom Binding: class SumCustomBinding extends Binding { @Override protected Number computeValue( Number object, String property, ValueFactory factory ) { return object.getNumberProperty( property ) + object.getNumberProperty( property ); } } But I would like to use the Bindings that allow me to just bind NumberProperty. As I understand it, if I can bind NumberProperty my task should be simplified. In Java, if I would like to do arithmetic I would define a static Object with @Binding annotated field and implement NumberProperty (as the example in this link). 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